The yeast plasma membrane proton pumping ATPase is a viable antifungal target. I. Effects of the cysteine-modifying reagent omeprazole.

@article{Monk1995TheYP,
  title={The yeast plasma membrane proton pumping ATPase is a viable antifungal target. I. Effects of the cysteine-modifying reagent omeprazole.},
  author={Brian C Monk and Alfred B Mason and Georgiy V. Abramochkin and James E Haber and Donna Seto-Young and David Scott Perlin},
  journal={Biochimica et biophysica acta},
  year={1995},
  volume={1239 1},
  pages={81-90}
}
The yeast plasma membrane proton pumping ATPase (H(+)-ATPase) was investigated as a potential molecular target for antifungal drug therapy by examining the inhibitory effects of the sulfhydryl-reactive reagent omeprazole on cell growth, glucose-induced medium acidification and H(+)-ATPase activity. Omeprazole inhibits the growth of Saccharomyces cerevisiae and the human pathogenic yeast Candida albicans in a pH dependent manner. Omeprazole action is closely correlated with inhibition of the H… CONTINUE READING