The yeast pheromone-responsive Gα protein stimulates recovery from chronic pheromone treatment by two mechanisms that are activated at distinct levels of stimulus

@article{Zhou1999TheYP,
  title={The yeast pheromone-responsive Gα protein stimulates recovery from chronic pheromone treatment by two mechanisms that are activated at distinct levels of stimulus},
  author={Jianlong Zhou and Michelle Arora and David E. Stone},
  journal={Cell Biochemistry and Biophysics},
  year={1999},
  volume={30},
  pages={193-212}
}
The pheromone response ofSaccharomyces cerevisiae is mediated by a receptor-coupled heterotrimeric G protein. The βγ subunit of the G protein stimulates a PAK/MAP kinase cascade that leads to cellular changes preparatory to mating, while the pheromone-responsive Gα protein, Gpa1, antagonizes the Gβγ-induced signal. In its inactive conformation, Gpa1 sequesters Gβγ and tethers it to the receptor. In its active conformation, Gpa1 stimulates adaptive mechanisms that downregulate the mating signal… CONTINUE READING