The yeast nuclear import receptor is required for mitosis.

@article{Loeb1995TheYN,
  title={The yeast nuclear import receptor is required for mitosis.},
  author={J D Loeb and Gabriel Schlenstedt and David Pellman and Daniel Kornitzer and Pamela A. Silver and Gerald Fink},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 17},
  pages={
          7647-51
        }
}
The nuclear import system is highly conserved among eukaryotes. Here we report the effects of a conditional mutation in SRP1, which encodes a Saccharomyces cerevisiae homolog of the vertebrate nuclear import receptor importin. Importin was isolated as a factor required for the initial targeting step of a nuclear import substrate to the nuclear envelope in a mammalian in vitro assay. We show that yeast Srp1 is similarly required for protein import. In addition, Srp1 is also required for the… CONTINUE READING

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