The yeast integral membrane protein Apq12 potentially links membrane dynamics to assembly of nuclear pore complexes

@article{Scarcelli2007TheYI,
  title={The yeast integral membrane protein Apq12 potentially links membrane dynamics to assembly of nuclear pore complexes},
  author={John J. Scarcelli and Christine A. Hodge and Charles N. Cole},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={178},
  pages={799 - 812}
}
Although the structure and function of components of the nuclear pore complex (NPC) have been the focus of many studies, relatively little is known about NPC biogenesis. In this study, we report that Apq12 is required for efficient NPC biogenesis in Saccharomyces cerevisiae. Apq12 is an integral membrane protein of the nuclear envelope (NE) and endoplasmic reticulum. Cells lacking Apq12 are cold sensitive for growth, and a subset of their nucleoporins (Nups), those that are primarily components… CONTINUE READING
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