The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p.

@article{Li1998TheYH,
  title={The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p.},
  author={Sheng Li and Alicia Ault and Cheryl Malone and Desmond C. Raitt and Susan Dean and L. H. Johnston and Robert J. Deschenes and Jan S. Fassler},
  journal={The EMBO journal},
  year={1998},
  volume={17 23},
  pages={6952-62}
}
The Saccharomyces cerevisiae Sln1 protein is a 'two-component' regulator involved in osmotolerance. Two-component regulators are a family of signal-transduction molecules with histidine kinase activity common in prokaryotes and recently identified in eukaryotes. Phosphorylation of Sln1p inhibits the HOG1 MAP kinase osmosensing pathway via a phosphorelay mechanism including Ypd1p and the response regulator, Ssk1p. SLN1 also activates an MCM1-dependent reporter gene, P-lacZ, but this function is… CONTINUE READING
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