The yeast VAS1 gene encodes both mitochondrial and cytoplasmic valyl-tRNA synthetases.

@article{Chatton1988TheYV,
  title={The yeast VAS1 gene encodes both mitochondrial and cytoplasmic valyl-tRNA synthetases.},
  author={Bruno Chatton and Philippe Walter and J. P. Ebel and François Lacroute and Franco Fasiolo},
  journal={The Journal of biological chemistry},
  year={1988},
  volume={263 1},
  pages={52-7}
}
S1 mapping on the VAS1 structural gene indicates the existence of two classes of transcripts initiating at distinct in-frame translation start codons. The longer class of VAS1 transcripts initiates upstream of both ATG codons located 138 base pairs away and the shorter class downstream of the first ATG. A mutation that destroys the first AUG on the long message results in respiratory deficiency but does not affect viability. Mutation of the ATG at position 139 leads to lethality because the… CONTINUE READING

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