The yeast SEC17 gene product is functionally equivalent to mammalian alpha-SNAP protein.

@article{Griff1992TheYS,
  title={The yeast SEC17 gene product is functionally equivalent to mammalian alpha-SNAP protein.},
  author={Irene C. Griff and Randy Schekman and James E Rothman and Chris A. Kaiser},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 17},
  pages={12106-15}
}
The SEC17 gene of Saccharomyces cerevisiae is required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Here we report that the product of the SEC17 gene has the exact biochemical properties expected for a yeast homologue of the mammalian transport factor, alpha-SNAP. The DNA sequence of SEC17 codes for a protein of predicted molecular mass of 33 kDa. Immunoblotting indicates that Sec17p fractionates as a peripheral membrane protein and is mostly soluble when… CONTINUE READING

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