The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1.

@article{Osada2001TheYS,
  title={The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1.},
  author={S. Osada and Ann Sutton and Nemone Muster and Christine E Brown and John R. Yates and Rolf Sternglanz and Jerry L. Workman},
  journal={Genes & development},
  year={2001},
  volume={15 23},
  pages={3155-68}
}
It is well established that acetylation of histone and nonhistone proteins is intimately linked to transcriptional activation. However, loss of acetyltransferase activity has also been shown to cause silencing defects, implicating acetylation in gene silencing. The something about silencing (Sas) 2 protein of Saccharomyces cerevisiae, a member of the MYST (MOZ, Ybf2/Sas3, Sas2, and TIP60) acetyltransferase family, promotes silencing at HML and telomeres. Here we identify a ~450-kD SAS complex… CONTINUE READING