The xeroderma pigmentosum group C gene polymorphisms and genetic susceptibility of nasopharyngeal carcinoma.

@article{Yang2008TheXP,
  title={The xeroderma pigmentosum group C gene polymorphisms and genetic susceptibility of nasopharyngeal carcinoma.},
  author={Zhi-hui Yang and Wei-bo Liang and Jing Jia and Ye-sheng Wei and Bin Zhou and Lin Zhang},
  journal={Acta oncologica},
  year={2008},
  volume={47 3},
  pages={379-84}
}
AIMS Nasopharyngeal cancer (NPC) is a multi-factorial disease, and the genetic background may be a crucial etiologic factor. The xeroderma pigmentosum complementation group C (XPC) is mainly involved in DNA damage repair, and the sequence variants in XPC gene may modulate DNA repair capacity and consequently lead to an individual's susceptibility to NPC. The aims of this study were to examine the association between XPC Val499Ala, Lys939Gln, PAT polymorphisms and the genetic susceptibility of… CONTINUE READING