The wound healing, chronic fibrosis, and cancer progression triad.

@article{Rybinski2014TheWH,
  title={The wound healing, chronic fibrosis, and cancer progression triad.},
  author={Brad Rybinski and Janusz Franco-Barraza and Edna Cukierman},
  journal={Physiological genomics},
  year={2014},
  volume={46 7},
  pages={223-44}
}
For decades tumors have been recognized as "wounds that do not heal." Besides the commonalities that tumors and wounded tissues share, the process of wound healing also portrays similar characteristics with chronic fibrosis. In this review, we suggest a tight interrelationship, which is governed as a concurrence of cellular and microenvironmental reactivity among wound healing, chronic fibrosis, and cancer development/progression (i.e., the WHFC triad). It is clear that the same cell types, as… CONTINUE READING
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