The wnt pathway: a macrophage effector molecule that triggers inflammation.

@article{Pereira2009TheWP,
  title={The wnt pathway: a macrophage effector molecule that triggers inflammation.},
  author={Claudia Pinto Pereira and Esther B. Bachli and Gabriele Schoedon},
  journal={Current atherosclerosis reports},
  year={2009},
  volume={11 3},
  pages={236-42}
}
Wnt proteins are members of the highly conserved wingless family of proteins responsible for cell differentiation and development and for neoplastic and degenerative processes. Recently, Toll-like receptor-mediated Wnt signaling was found to be associated with innate immunity in Drosophila. Upregulation of Wnt5A in human macrophages upon microbial challenge indicated a similar mechanism. Toll-like receptor-mediated Wnt5A expression is a key process for sustained inflammatory macrophage… CONTINUE READING

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