The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast.

@article{Stettler1996TheWS,
  title={The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast.},
  author={Sandra Stettler and E Vicky Warbrick and S Prochnik and Shaun Mackie and Peter A. Fantes},
  journal={Journal of cell science},
  year={1996},
  volume={109 ( Pt 7)},
  pages={1927-35}
}
The wis1 protein kinase of Schizosaccharomyces pombe is a member of the MAP kinase kinase family. Loss of wis1 function has previously been reported to lead to a delay in the G2-mitosis transition, loss of viability in stationary phase, and hypersensitivity to osmotic shock. It acts at least in part by activating the MAP kinase homologue sty1; loss-of-function sty1 mutants share many phenotypes with wis1 deletion mutants. We show here that, in addition, loss of wis1 function leads to defective… CONTINUE READING

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