The wing in yeast heat shock transcription factor (HSF) DNA-binding domain is required for full activity.


The yeast heat shock transcription factor (HSF) belongs to the winged helix family of proteins. HSF binds DNA as a trimer, and additional trimers can bind DNA co-operatively. Unlike other winged helix-turn-helix proteins, HSF's wing does not appear to contact DNA, as based on a previously solved crystal structure. Instead, the structure implies that the… (More)


  • Presentations referencing similar topics