The winding path of protein methylation research: milestones and new frontiers

@article{Murn2017TheWP,
  title={The winding path of protein methylation research: milestones and new frontiers},
  author={J. Murn and Y. Shi},
  journal={Nature Reviews Molecular Cell Biology},
  year={2017},
  volume={18},
  pages={517-527}
}
  • J. Murn, Y. Shi
  • Published 2017
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • In 1959, while analysing the bacterial flagellar proteins, Ambler and Rees observed an unknown species of amino acid that they eventually identified as methylated lysine. Over half a century later, protein methylation is known to have a regulatory role in many essential cellular processes that range from gene transcription to signal transduction. However, the road to this now burgeoning research field was obstacle-ridden, not least because of the inconspicuous nature of the methyl mark itself… CONTINUE READING

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