27 Citations
Three-dimensional simulation of the Caenorhabditis elegans body and muscle cells in liquid and gel environments for behavioural analysis
- BiologyPhilosophical Transactions of the Royal Society B: Biological Sciences
- 2018
A three-dimensional computational biomechanical model of the Caenorhabditis elegans body based on real anatomical structure is created with a particle system–based simulation engine known as Sibernetic, which implements the smoothed particle–hydrodynamics algorithm.
Whole integration of neural connectomics, dynamics and bio-mechanics for identification of behavioral sensorimotor pathways in Caenorhabditis elegans
- Biology, PsychologybioRxiv
- 2019
Results show how an ablation survey can identify neurons required for a ventral turning behavior and how conditional ablation can identify alternative novel neural pathways, e.g. propose neurons which facilitate steering behavior towards olfactory attractants.
The control structure of the nematode Caenorhabditis elegans: Neuro-sensory integration and proprioceptive feedback.
- BiologyJournal of biomechanics
- 2018
Role of simulation models in understanding the generation of behavior in C. elegans
- BiologyCurrent Opinion in Systems Biology
- 2019
Novel Technological Advances in Functional Connectomics in C. elegans
- BiologyJournal of developmental biology
- 2019
Recent technological advances used to analyze and perturb whole-organism neuronal function along with developments in computational modeling are discussed, which allows for interrogation of both local and global neural circuits, leading to different behaviors.
The Si elegans project at the interface of experimental and computational Caenorhabditis elegans neurobiology and behavior.
- BiologyJournal of neural engineering
- 2016
OBJECTIVE
In light of recent progress in mapping neural function to behavior, we briefly and selectively review past and present endeavors to reveal and reconstruct nervous system function in…
A Single-Cell Level and Connectome-Derived Computational Model of the Drosophila Brain
- BiologyFront. Neuroinform.
- 2019
The reconstructed Drosophila brain was structurally and dynamically more diverse than the randomized one and exhibited both Poisson-like and patterned firing activities and compared the reconstructed brain network with a randomized brain network by shuffling the connections of each neuron.
A single-cell level and connectome-derived computational model of the Drosophila brain
- BiologybioRxiv
- 2018
The reconstructed Drosophila brain was structurally and dynamically more diverse than the randomized one and exhibited both Poisson-like and patterned firing activities and compared the reconstructed brain network with a randomized brain network by shuffling the connections of each neuron.
Information theory rules out the reflex-chain model of C. elegans locomotion
- BiologybioRxiv
- 2022
It is found that the reflex-chain model can be refuted, in both forward and backward locomotion as well as during swimming and crawling behaviors, and it is shown that information theory applied to animal behavior can yield insights into the neural control of behavior.
Vulnerability-Based Critical Neurons, Synapses, and Pathways in the Caenorhabditis elegans Connectome
- BiologyPLoS Comput. Biol.
- 2016
The vulnerability of the Caenorhabditis elegans connectome was investigated by performing computational experiments that “attacked” 279 individual neurons and 2,990 weighted synaptic connections and quantified the effects of each removal on global network properties that influence information processing.
References
SHOWING 1-10 OF 77 REFERENCES
An Integrated Neuro-mechanical Model of C. elegansForward Locomotion
- Biology, EngineeringICONIP
- 2007
It is found that a previous neural model is robust to the addition of a body with mechanical properties, and that the integrated model produces oscillations with a more realistic frequency and waveform than the neural model alone.
Nematode locomotion: dissecting the neuronal–environmental loop
- Biology, PsychologyCurrent Opinion in Neurobiology
- 2014
Gait Modulation in C. elegans: An Integrated Neuromechanical Model
- BiologyFront. Comput. Neurosci.
- 2012
A model of C. elegans forward locomotion is presented that includes a neuromuscular control system that relies on a sensory feedback mechanism to generate undulations and is integrated with a physical model of the body and environment and reproduces the entire swim-crawl transition with no modulatory mechanism.
Neurobiology of Caenorhabditis elegans Locomotion: Where Do We Stand?
- BiologyBioscience
- 2014
The nematode Caenorhabditis elegans is used for detailed studies of genetic and physiological locomotion mechanisms, and locomotion behavior, the parts constituting the locomotion system, and the relevant neuronal connectivity are described.
Deciphering the Neural and Molecular Mechanisms of C. elegans Behavior
- BiologyCurrent Biology
- 2005
C. elegans locomotion: small circuits, complex functions
- BiologyCurrent Opinion in Neurobiology
- 2015
A Biologically Accurate 3D Model of the Locomotion of Caenorhabditis Elegans
- Biology2010 International Conference on Biosciences
- 2010
This work presents a biologically accurate, 3-dimensional model of C. elegans that takes into account many facets of the organism including size, shape, weight distribution, muscle placement, and muscle force, and explicitly model the environment of the worm to include factors such as contact, friction, inertia, and gravity.
Training sensory-motor behavior in the connectome of an artificial C. elegans
- BiologyNeurocomputing
- 2015
Biological modeling the undulatory locomotion of C. elegans using dynamic neural network approach
- Biology, EngineeringNeurocomputing
- 2016
Systems level circuit model of C. elegans undulatory locomotion: mathematical modeling and molecular genetics
- BiologyJournal of Computational Neuroscience
- 2007
The model reveals that stretch receptor coupling in the body wall is critical for generation of the neuromuscular wave, and agrees with behavioral data and with other pertinent published data, e.g., that frequency is an increasing function of muscle gap-junction coupling.