The whole worm: brain–body–environment models of C. elegans 

@article{Izquierdo2016TheWW,
  title={The whole worm: brain–body–environment models of C. elegans
},
  author={Eduardo J. Izquierdo and Randall D. Beer},
  journal={Current Opinion in Neurobiology},
  year={2016},
  volume={40},
  pages={23-30}
}
View on Elsevier
manuscript.elsevier.com
27 Citations
Background Citations
7
Methods Citations
1

Figures from this paper

27 Citations

Citation Type

Citation Type

Three-dimensional simulation of the Caenorhabditis elegans body and muscle cells in liquid and gel environments for behavioural analysis
TLDR
A three-dimensional computational biomechanical model of the Caenorhabditis elegans body based on real anatomical structure is created with a particle system–based simulation engine known as Sibernetic, which implements the smoothed particle–hydrodynamics algorithm.
Whole integration of neural connectomics, dynamics and bio-mechanics for identification of behavioral sensorimotor pathways in Caenorhabditis elegans
TLDR
Results show how an ablation survey can identify neurons required for a ventral turning behavior and how conditional ablation can identify alternative novel neural pathways, e.g. propose neurons which facilitate steering behavior towards olfactory attractants.
The control structure of the nematode Caenorhabditis elegans: Neuro-sensory integration and proprioceptive feedback.
Role of simulation models in understanding the generation of behavior in C. elegans
Novel Technological Advances in Functional Connectomics in C. elegans
TLDR
Recent technological advances used to analyze and perturb whole-organism neuronal function along with developments in computational modeling are discussed, which allows for interrogation of both local and global neural circuits, leading to different behaviors.
The Si elegans project at the interface of experimental and computational Caenorhabditis elegans neurobiology and behavior.
OBJECTIVE In light of recent progress in mapping neural function to behavior, we briefly and selectively review past and present endeavors to reveal and reconstruct nervous system function in…
A Single-Cell Level and Connectome-Derived Computational Model of the Drosophila Brain
TLDR
The reconstructed Drosophila brain was structurally and dynamically more diverse than the randomized one and exhibited both Poisson-like and patterned firing activities and compared the reconstructed brain network with a randomized brain network by shuffling the connections of each neuron.
A single-cell level and connectome-derived computational model of the Drosophila brain
TLDR
The reconstructed Drosophila brain was structurally and dynamically more diverse than the randomized one and exhibited both Poisson-like and patterned firing activities and compared the reconstructed brain network with a randomized brain network by shuffling the connections of each neuron.
Information theory rules out the reflex-chain model of C. elegans locomotion
TLDR
It is found that the reflex-chain model can be refuted, in both forward and backward locomotion as well as during swimming and crawling behaviors, and it is shown that information theory applied to animal behavior can yield insights into the neural control of behavior.
Vulnerability-Based Critical Neurons, Synapses, and Pathways in the Caenorhabditis elegans Connectome
TLDR
The vulnerability of the Caenorhabditis elegans connectome was investigated by performing computational experiments that “attacked” 279 individual neurons and 2,990 weighted synaptic connections and quantified the effects of each removal on global network properties that influence information processing.
...
1
2
3
...

References

SHOWING 1-10 OF 77 REFERENCES
An Integrated Neuro-mechanical Model of C. elegansForward Locomotion
TLDR
It is found that a previous neural model is robust to the addition of a body with mechanical properties, and that the integrated model produces oscillations with a more realistic frequency and waveform than the neural model alone.
Nematode locomotion: dissecting the neuronal–environmental loop
Gait Modulation in C. elegans: An Integrated Neuromechanical Model
TLDR
A model of C. elegans forward locomotion is presented that includes a neuromuscular control system that relies on a sensory feedback mechanism to generate undulations and is integrated with a physical model of the body and environment and reproduces the entire swim-crawl transition with no modulatory mechanism.
Neurobiology of Caenorhabditis elegans Locomotion: Where Do We Stand?
TLDR
The nematode Caenorhabditis elegans is used for detailed studies of genetic and physiological locomotion mechanisms, and locomotion behavior, the parts constituting the locomotion system, and the relevant neuronal connectivity are described.
Deciphering the Neural and Molecular Mechanisms of C. elegans Behavior
C. elegans locomotion: small circuits, complex functions
A Biologically Accurate 3D Model of the Locomotion of Caenorhabditis Elegans
TLDR
This work presents a biologically accurate, 3-dimensional model of C. elegans that takes into account many facets of the organism including size, shape, weight distribution, muscle placement, and muscle force, and explicitly model the environment of the worm to include factors such as contact, friction, inertia, and gravity.
Training sensory-motor behavior in the connectome of an artificial C. elegans
Biological modeling the undulatory locomotion of C. elegans using dynamic neural network approach
Systems level circuit model of C. elegans undulatory locomotion: mathematical modeling and molecular genetics
TLDR
The model reveals that stretch receptor coupling in the body wall is critical for generation of the neuromuscular wave, and agrees with behavioral data and with other pertinent published data, e.g., that frequency is an increasing function of muscle gap-junction coupling.
...
1
2
3
4
5
...