The who, how and where of antigen presentation to B cells

  title={The who, how and where of antigen presentation to B cells},
  author={Facundo D Batista and Naomi E. Harwood},
  journal={Nature Reviews Immunology},
A functional immune system depends on the appropriate activation of lymphocytes following antigen encounter. In this Review, we summarize studies that have used high-resolution imaging approaches to visualize antigen presentation to B cells in secondary lymphoid organs. These studies illustrate that encounters of B cells with antigen in these organs can be facilitated by diffusion of the antigen or by the presentation of antigen by macrophages, dendritic cells and follicular dendritic cells. We… CONTINUE READING
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