The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain.

@article{Schddekopf1996TheWT,
  title={The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain.},
  author={K Sch{\"u}ddekopf and Michael Schorpp and T. Ritschel R. B{\"o}hm},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 18},
  pages={9661-4}
}
Mutations in the whn gene are associated with the phenotype of congenital athymia and hairlessness in mouse and rat. The whn gene encodes a presumptive transcription factor with a DNA binding domain of the forkhead/ winged-helix class. Two previously described null alleles encode truncated whn proteins lacking the characteristic DNA binding domain. In the rat rnu allele described here, a nonsense mutation in exon 8 of the whn gene was identified. The truncated whnrnu protein contains the DNA… CONTINUE READING
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