The where and when of T cell regulation in transplantation.

  title={The where and when of T cell regulation in transplantation.},
  author={F. Issa and Renee J Robb and Kathryn J. Wood},
  journal={Trends in immunology},
  volume={34 3},
Multiple cell types contribute to the peripheral regulation of T cell alloresponses in haematopoieitc cell transplantation (HCT) and solid organ transplantation (SOT). Of these, regulatory T cells (Tregs) are the principal players and have shown the greatest success in the therapeutic control of detrimental immune responses. Investigations into the induction, location, and mechanism of suppression utilised by Tregs to control alloreactive responses are ongoing. The activation and homing… CONTINUE READING
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