The weaver mutation causes a loss of inward rectifier current regulation in premigratory granule cells of the mouse cerebellum.

@article{Rossi1998TheWM,
  title={The weaver mutation causes a loss of inward rectifier current regulation in premigratory granule cells of the mouse cerebellum.},
  author={Paola Rossi and Giovanna De Filippi and Simona Armano and Vanni Taglietti and Edgardo D'Angelo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 10},
  pages={
          3537-47
        }
}
Considerable interest has recently focused on the weaver mutation, which causes inward rectifier channel alterations leading to profound impairment of neuronal differentiation and to severe motor dysfunction in mice (Hess, 1996). The principal targets of mutation are cerebellar granule cells, most of which fail to differentiate and degenerate in a premigratory position (Rakic and Sidman, 1973a,b). Two hypotheses have been put forward to explain the pathogenetic role of mutant inward rectifier… CONTINUE READING

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