The warfarin–cranberry juice interaction revisited: A systematic in vitro–in vivo evaluation

@inproceedings{Ngo2010TheWJ,
  title={The warfarin–cranberry juice interaction revisited: A systematic in vitro–in vivo evaluation},
  author={Ngoc Son Ngo and Scott J Brantley and Daniel R Carrizosa and Angela D. M. Kashuba and Elizabeth Claire Dees and David J. Kroll and Nicholas H Oberlies and Mary Paine},
  booktitle={Journal of experimental pharmacology},
  year={2010}
}
BACKGROUND: Cranberry products have been implicated in several case reports to enhance the anticoagulant effect of warfarin. The mechanism could involve inhibition of the hepatic CYP2C9-mediated metabolic clearance of warfarin by components in cranberry. Because dietary/natural substances vary substantially in bioactive ingredient composition, multiple cranberry products were evaluated in vitro before testing this hypothesis in vivo. METHODS: The inhibitory effects of five types of cranberry… CONTINUE READING