The wake-promoting transmitter histamine preferentially enhances alpha-4 subunit-containing GABAA receptors

@article{Bianchi2011TheWT,
  title={The wake-promoting transmitter histamine preferentially enhances alpha-4 subunit-containing GABAA receptors},
  author={Matt T. Bianchi and Alison G. Clark and Janet L. Fisher},
  journal={Neuropharmacology},
  year={2011},
  volume={61},
  pages={747-752}
}
Histamine is an important wake-promoting neurotransmitter that activates seven-transmembrane G-protein coupled histamine receptors. However, histamine demonstrates target promiscuity, including direct interaction with the structurally unrelated glutamate (NMDA) and GABA(A) receptor channels. Previous work showed that histamine enhances the activity of recombinant GABA(A) receptor isoforms typically found in synaptic locations, although co-release of histamine and GABA is not known to occur in… CONTINUE READING