The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization.

@article{Eggermann2003TheWH,
  title={The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization.},
  author={Emmanuel Eggermann and L. Batlle Bayer and Mauro Serafin and Beno{\^i}t Saint-Mleux and Laurent Bernheim and Dani{\`e}le Machard and Barbara E Jones and Michel M{\"u}hlethaler},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 5},
  pages={1557-62}
}
Wakefulness depends on the activity of hypocretin-orexin neurons because their lesion results in narcolepsy. How these neurons maintain their activity to promote wakefulness is not known. Here, by recording for the first time from hypocretin-orexin neurons and comparing their properties with those of neurons expressing melanin-concentrating hormone, we show that hypocretin-orexin neurons are in an intrinsic state of membrane depolarization that promotes their spontaneous activity. We propose… CONTINUE READING

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Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response.

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