The von Hippel–Lindau tumour suppressor gene: uncovering the expression of the pVHL172 isoform

@inproceedings{Chesnel2015TheVH,
  title={The von Hippel–Lindau tumour suppressor gene: uncovering the expression of the pVHL172 isoform},
  author={Franck Chesnel and P Hascoet and Jean-Philippe Gagn{\'e} and Anne Couturier and Florence Jouan and Guy G. Poirier and Catherine Le Goff and C{\'e}cile Vigneau and Y Danger and Fabien Verite and Xavier Fr{\'e}d{\'e}ric Le Goff and Yannick Arlot-Bonnemains},
  booktitle={British Journal of Cancer},
  year={2015}
}
Background:The von Hippel–Lindau (VHL) gene encodes two mRNA variants. Variant 1 encodes two protein isoforms, pVHL213 and pVHL160, that have been extensively documented in the literature. Variant 2 is produced by alternative splicing of exon 2 and encodes a pVHL isoform of 172 amino acids with a theoretical molecular weight of 19 kDa (pVHL172), the… CONTINUE READING