The voltage-sensitive sodium channel is a bell-shaped molecule with several cavities

@article{Sato2001TheVS,
  title={The voltage-sensitive sodium channel is a bell-shaped molecule with several cavities},
  author={Chikara Sato and Yutaka Ueno and Kiyoshi Asai and K Takahashi and M Sato and Andreas Engel and Yoshinori Fujiyoshi},
  journal={Nature},
  year={2001},
  volume={409},
  pages={1047-1051}
}
Voltage-sensitive membrane channels, the sodium channel, the potassium channel and the calcium channel operate together to amplify, transmit and generate electric pulses in higher forms of life. Sodium and calcium channels are involved in cell excitation, neuronal transmission, muscle contraction and many functions that relate directly to human diseases. Sodium channels—glycosylated proteins with a relative molecular mass of about 300,000 (ref. 5)—are responsible for signal transduction and… Expand
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