The voltage-gated sodium channel beta2-subunit gene and idiopathic generalized epilepsy.

@article{Haug2000TheVS,
  title={The voltage-gated sodium channel beta2-subunit gene and idiopathic generalized epilepsy.},
  author={Karsten Haug and Thomas K. Sander and Kerstin Hallmann and B. Ramarishna Rau and Joern S. Dullinger and Christian Erich Elger and P. Propping and Armin Heils},
  journal={Neuroreport},
  year={2000},
  volume={11 12},
  pages={2687-9}
}
Recent identification of ion channel gene mutations in Mendelian epilepsies suggests that genetically driven neuronal hyperexcitability plays an important role in epileptogenesis. In this study, we tested the hypothesis that genetic variation in the human SCN2B gene confers liability to common subtypes of idiopathic generalized epilepsies (IGE). A… CONTINUE READING