The voltage-gated potassium channels and their relatives

@article{Yellen2002TheVP,
  title={The voltage-gated potassium channels and their relatives},
  author={Gary Yellen},
  journal={Nature},
  year={2002},
  volume={419},
  pages={35-42}
}
  • G. Yellen
  • Published 2002
  • Chemistry, Medicine
  • Nature
The voltage-gated potassium channels are the prototypical members of a family of membrane signalling proteins. These protein-based machines have pores that pass millions of ions per second across the membrane with astonishing selectivity, and their gates snap open and shut in milliseconds as they sense changes in voltage or ligand concentration. The architectural modules and functional components of these sophisticated signalling molecules are becoming clear, but some important links remain to… Expand
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610 Citations
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610 Citations

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  • U. Lee, J. Cui
  • Chemistry, Medicine
  • Trends in Neurosciences
  • 2010
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Recently published electron cryomicroscopy and X-ray crystallographic structures of the BK channel provided the first glimpse into the assembly of these domains, corroborating the close interactions among these domains during channel gating that have been suggested by functional studies. Expand
The Domain and Conformational Organization in Potassium Voltage-Gated Ion Channels
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