The voltage-gated calcium channel functions as the molecular switch of synaptic transmission.

@article{Atlas2013TheVC,
  title={The voltage-gated calcium channel functions as the molecular switch of synaptic transmission.},
  author={Daphne Atlas},
  journal={Annual review of biochemistry},
  year={2013},
  volume={82},
  pages={607-35}
}
Transmitter release is a fast Ca(2+)-dependent process triggered in response to membrane depolarization. It involves two major calcium-binding proteins, the voltage-gated calcium channel (VGCC) and the vesicular protein synaptotagmin (syt1). Ca(2+) binding triggers transmitter release with a time response of conformational changes that are too fast to be accounted for by Ca(2+) binding to syt1. In contrast, conformation-triggered release, which engages Ca(2+) binding to VGCC, better accounts… CONTINUE READING