The vitamin D receptor gene FokI polymorphism: functional impact on the immune system.

@article{Etten2007TheVD,
  title={The vitamin D receptor gene FokI polymorphism: functional impact on the immune system.},
  author={Evelyne van Etten and Lieve Verlinden and Annapaula Giulietti and Elizabeth Ramos-Lopez and Dumitru D. Branisteanu and Gabriela Bonfim Ferreira and Lut Overbergh and Annemieke Verstuyf and R Bouillon and Bart O Roep and Klaus Badenhoop and Chantal Mathieu},
  journal={European journal of immunology},
  year={2007},
  volume={37 2},
  pages={395-405}
}
1Alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) has important effects on the growth and function of multiple cell types. These pleiotropic effects of 1,25(OH)2D3 are mediated through binding to the vitamin D receptor (VDR). Several polymorphisms of the human VDR gene have been identified, with the FokI polymorphism resulting in VDR proteins with different structures, a long f-VDR or a shorter F-VDR. The aim of this study was to investigate the functional consequences of the FokI polymorphism in… CONTINUE READING