The vitamin D receptor activator paricalcitol prevents fibrosis and diastolic dysfunction in a murine model of pressure overload.

@article{Meems2012TheVD,
  title={The vitamin D receptor activator paricalcitol prevents fibrosis and diastolic dysfunction in a murine model of pressure overload.},
  author={Laura M. G. Meems and Megan V. Cannon and Hasan Mahmud and Adriaan Alexander Voors and Wiek H van Gilst and Herman H W Sillj{\'e} and Willem P. T. Ruifrok and Rudolf A de Boer},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2012},
  volume={132 3-5},
  pages={282-9}
}
BACKGROUND Activation of the vitamin D-vitamin D receptor (VDR) axis has been shown to reduce blood pressure and left ventricular (LV) hypertrophy. Besides cardiac hypertrophy, cardiac fibrosis is a key element of adverse cardiac remodeling. We hypothesized that activation of the VDR by paricalcitol would prevent fibrosis and LV diastolic dysfunction in an established murine model of cardiac remodeling. METHODS Mice were subjected to transverse aortic constriction (TAC) to induce cardiac… CONTINUE READING
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