The vitamin D receptor, the skin and stem cells.

  title={The vitamin D receptor, the skin and stem cells.},
  author={Hilary F Luderer and Marie B Demay},
  journal={The Journal of steroid biochemistry and molecular biology},
  volume={121 1-2},
The active metabolite of vitamin D, 1,25-dihydroxyvitamin D, has been shown to have pro-differentiation and antiproliferative effects on keratinocytes that are mediated by interactions with its nuclear receptor. Other cutaneous actions of the vitamin D receptor have been brought to light by the cutaneous phenotype of humans and mice with non-functional vitamin D receptors. Although mice lacking functional vitamin D receptors develop a normal first coat of hair, they exhibit impaired cyclic… CONTINUE READING


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