The viral oncogene human papillomavirus E7 deregulates transcriptional silencing by Brm-related gene 1 via molecular interactions.

Abstract

BRG-1, a component of the human SWI/SNF complex, either activates or represses cellular promoters by modulating chromatin structure via the formation of a multiple polypeptide complex. Human papillomavirus E7 binds and destabilizes pRb, resulting in the blockage of G(1) arrest in the cell cycle. We show here that the high-risk human papillomavirus E7… (More)

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@article{Lee2002TheVO, title={The viral oncogene human papillomavirus E7 deregulates transcriptional silencing by Brm-related gene 1 via molecular interactions.}, author={Daeyoup Lee and Chunghun Lim and Taegun Seo and Hyockman Kwon and Hyesun Min and Joonho Choe}, journal={The Journal of biological chemistry}, year={2002}, volume={277 50}, pages={48842-8} }