The viral mimic, polyinosinic:polycytidylic acid, induces fever in rats via an interleukin-1-dependent mechanism.

  title={The viral mimic, polyinosinic:polycytidylic acid, induces fever in rats via an interleukin-1-dependent mechanism.},
  author={Marie-{\`E}ve Fortier and Stephen Kent and Helen F. Ashdown and Stephen Poole and Patricia Boksa and Giamal N. Luheshi},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={287 4},
  • M. FortierS. Kent G. Luheshi
  • Published 1 October 2004
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
Polyinosinic:polycytidylic acid (poly I:C) is a synthetic double-stranded RNA that is used experimentally to model viral infections in vivo. Previous studies investigating the inflammatory properties of this agent in rodents demonstrated that it is a potent pyrogen. However, the mechanisms underlying this response have not been fully elucidated. In the current study, we examined the effects of peripheral administration of poly I:C on body temperature and cytokine production. Male rats were… 

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