The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin-interacting protein 1.

@article{Cheng2003TheVD,
  title={The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin-interacting protein 1.},
  author={Chih Mei Cheng and Shiao-ping Huang and Yung-Fu Chang and Wen-Yuan Chung and C Y Yuo},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={305 2},
  pages={359-64}
}
Apoptin, a chicken anemia virus-encoded protein, induces apoptosis in human tumor cells but not in normal cells. The tumor-specific activity of Apoptin is correlated with its nuclear localization in tumor cells. In an attempt to elucidate the molecular mechanism of Apoptin-induced apoptosis, we identified human Hippi, the protein interactor and apoptosis co-mediator of Huntingtin interacting protein 1, as one of the Apoptin-associated proteins by yeast two-hybrid screen. We also demonstrated… CONTINUE READING

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