The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection

  title={The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection},
  author={Leen Delang and Chensi Li and Ali İhsan Taş and Gilles Qu{\'e}rat and Irina Cristina Albulescu and Tine De Burghgraeve and N. A. Segura Guerrero and Alba Gigante and G{\'e}raldine Piorkowski and Etienne Decroly and Dirk Jochmans and Bruno Canard and Eric J. Snijder and Mar{\'i}a Jes{\'u}s P{\'e}rez-P{\'e}rez and Martijn J. van Hemert and Bruno Coutard and Pieter Leyssen and Johan Neyts},
  booktitle={Scientific reports},
The chikungunya virus (CHIKV) has become a substantial global health threat due to its massive re-emergence, the considerable disease burden and the lack of vaccines or therapeutics. We discovered a novel class of small molecules ([1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones) with potent in vitro activity against CHIKV isolates from different geographical regions. Drug-resistant variants were selected and these carried a P34S substitution in non-structural protein 1 (nsP1), the main enzyme… CONTINUE READING
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