The viral Tat protein has no essential function in HIV-1 replication other than to activate transcription

@article{Das2009TheVT,
  title={The viral Tat protein has no essential function in HIV-1 replication other than to activate transcription},
  author={Atze T. Das and Alex Harwig and Ben Berkhout},
  journal={Retrovirology},
  year={2009},
  volume={6},
  pages={P24 - P24}
}
It is generally accepted that the Tat protein has a pivotal role in HIV-1 replication because it activates transcription from the viral LTR promoter through binding of the TAR hairpin in the nascent RNA transcript. However, several other functions of Tat have been suggested in e.g. HIV-1 RNA translation, reverse transcription and RNAi suppression. How… CONTINUE READING