The villin-like protein encoded by the Drosophila quail gene is required for actin bundle assembly during oogenesis.

@article{MahajanMiklos1994TheVP,
  title={The villin-like protein encoded by the Drosophila quail gene is required for actin bundle assembly during oogenesis.},
  author={S Mahajan-Miklos and Lynn Cooley},
  journal={Cell},
  year={1994},
  volume={78 2},
  pages={291-301}
}
Mutations in the Drosophila quail gene result in female sterility due to the disruption of cytoplasmic transport from the nurse cells into the oocyte late in oogenesis. Nurse cells from quail mutant egg chambers fail to assemble cytoplasmic actin filament bundles correctly. We have cloned the quail gene and found that it encodes a protein with homology to the vertebrate actin-regulating protein villin. Unlike vertebrate villin, which is restricted to specialized absorptive epithelial cells, the… CONTINUE READING

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