The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: Implications for pharmacological models of parkinsonian tremor

@article{Podurgiel2013TheVM,
  title={The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: Implications for pharmacological models of parkinsonian tremor},
  author={Samantha J. Podurgiel and Eric J. Nunes and Samantha E. Yohn and J. Barber and Analisa T Thompson and Melissa Anne Milligan and Cin-Ty A. Lee and Laura L{\'o}pez-Cruz and M. E. Pardo and Olga Valverde and C Lendent and Younis Baqi and Christa E. M{\"u}ller and M. J. Duarte Correa and John D Salamone},
  journal={Neuroscience},
  year={2013},
  volume={250},
  pages={507-519}
}
Tetrabenazine (TBZ) is a reversible inhibitor of vesicular monoamine storage that is used to treat Huntington's disease. TBZ preferentially depletes striatal dopamine (DA), and patients being treated with TBZ often experience parkinsonian side effects. The present studies were conducted to investigate the ability of TBZ to induce tremulous jaw movements (TJMs), which are a rodent model of parkinsonian tremor, and to determine if interference with adenosine A2A receptor transmission can… CONTINUE READING
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