The versatility of oligonucleotides as potential therapeutics

@article{Eckstein2007TheVO,
  title={The versatility of oligonucleotides as potential therapeutics},
  author={Fritz Eckstein},
  journal={Expert Opinion on Biological Therapy},
  year={2007},
  volume={7},
  pages={1021 - 1034}
}
  • F. Eckstein
  • Published 1 July 2007
  • Biology, Medicine
  • Expert Opinion on Biological Therapy
Oligonucleotides can in a variety of ways inhibit gene expression by interfering with translation. Oligonucleotides that are complementary to a target mRNA, antisense oligonucleotides, can prevent translation either by cleaving the target or by physically blocking the process. Additionally, oligonucleotides can correct the undesired splicing of pre-mRNA. RNA interference using double-stranded oligoribonucleotides also results in cleavage of the target mRNA. Catalytically competent ribozymes and… 
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TLDR
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