The versatility of Helicobacter pylori CagA effector protein functions: The master key hypothesis.

@article{Backert2010TheVO,
  title={The versatility of Helicobacter pylori CagA effector protein functions: The master key hypothesis.},
  author={Steffen Backert and Nicole Tegtmeyer and Matthias Selbach},
  journal={Helicobacter},
  year={2010},
  volume={15 3},
  pages={163-76}
}
Several bacterial pathogens inject virulence proteins into host target cells that are substrates of eukaryotic tyrosine kinases. One of the key examples is the Helicobacter pylori CagA effector protein which is translocated by a type-IV secretion system. Injected CagA becomes tyrosine-phosphorylated on EPIYA sequence motifs by Src and Abl family kinases. CagA then binds to and activates/inactivates multiple signaling proteins in a phosphorylation-dependent and phosphorylation-independent manner… CONTINUE READING

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