The versatility and complexity of calcium signalling.

  title={The versatility and complexity of calcium signalling.},
  author={Michael J. Berridge},
  journal={Novartis Foundation symposium},
  pages={52-64; discussion 64-7, 150-9}
Ca2+ is a universal second messenger used to regulate a wide range of cellular processes such as fertilization, proliferation, contraction, secretion, learning and memory. Cells derive signal Ca2+ from both internal and external sources. The Ca2+ flowing through these channels constitute the elementary events of Ca2+ signalling. Ca2+ can act within milliseconds in highly localized regions or it can act much more slowly as a global wave that spreads the signal throughout the cell. Various pumps… CONTINUE READING