The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease.

p300 and CBP are highly homologous coactivators which promote gene transcription by bridging between DNA-binding transcription factors and the basal transcription machinery, by providing a scaffold for integrating transcription factors, and by modifying transcription factors and chromatin through acetylation. The p300/CBP cofactors are involved in a… CONTINUE READING