The versatile functions of Sox9 in development, stem cells, and human diseases

@inproceedings{Jo2014TheVF,
  title={The versatile functions of Sox9 in development, stem cells, and human diseases},
  author={Alice Jo and Sahitya K. Denduluri and Bosi Zhang and Zhongliang Wang and Liangjun Yin and Zhengjian Yan and Richard W. Kang and Lewis L. Shi and James M Mok and Michael J. Lee and Rex C. Haydon},
  booktitle={Genes & diseases},
  year={2014}
}
The transcription factor Sox9 was first discovered in patients with campomelic dysplasia, a haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 expression during chondrogenesis. Since then, its role as a cell fate determiner during embryonic development has been well characterized; Sox9 expression differentiates cells derived from all three germ layers into a large variety of specialized tissues and organs. However, recent data has shown that ectoderm- and… CONTINUE READING

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