The venom of the Colombian arrow poison frogPhyllobates bicolor

@article{Mrki2005TheVO,
  title={The venom of the Colombian arrow poison frogPhyllobates bicolor},
  author={Fritz M{\"a}rki and Bernhard Witkop},
  journal={Experientia},
  year={2005},
  volume={19},
  pages={329-338}
}
Ein hochaktives Gift mit einer LD50 von mindestens 2.7 ± 0.2 µg/kg Maus wurde aus der Haut des columbischen PfeilgiftfroschesPhyllobates bicolor isoliert. Nach 60 facher Anreicherung erwies sich das Produkt in der Dünnschichtchromatographie als einheitlich. Es ist löslich in organischen Lösungsmitteln wie Chloroform und Methylenchlorid und lässt sich aus solchen Lösungen mit wässriger Säure extrahieren. Aus dem Verteilungsverhalten der Aktivität bei verschiedenen pH-Werten wurden pK-Werte von 7… 
Chemie und Biochemie von Amphibiengaiften
Die zahlreichen giftigen Tiere unserer Erde lassen sich grob in zwei .Klassen unterteilen : aktiv and passiv giftige Tiere. Zur ersten Gruppe zählt man solche, die ihre Beute mit Hilfe von
Poor alkaloid sequestration by arrow poison frogs of the genus Phyllobates from Costa Rica.
TLDR
The Phyllobates species are poorly sequestering alkaloids from their food source in contrast to the Dendrobates frogs, whose feeding pattern is similar as revealed by examination of their stomach content.
Biologically Active Alkaloids from Poison Frogs (Dendrobatidae)
TLDR
Five major classes have been defined: the highly toxic batrachotoxins are steroidal alkaloids which prevent interactivation of sodium channels in nerve and muscle, and pumiliotoxin-C class alkaloid are decahydroquinolines which block nicotinic receptor mediated neuromuscular transmission.
A Review of Chemical Defense in Poison Frogs (Dendrobatidae): Ecology, Pharmacokinetics, and Autoresistance
TLDR
A summary of the ecological and evolutionary contexts underlying the origin and maintenance of chemical defenses across Dendrobatidae is presented and aspects of the pharmacokinetics of acquiring defensive substances in these amphibians are reviewed.
PHYLOGENETIC SYSTEMATICS OF DART-POISON FROGS AND THEIR RELATIVES (AMPHIBIA: ATHESPHATANURA: DENDROBATIDAE)
TLDR
A new, monophyletic taxonomy for dendrobatids is proposed, recognizing the inclusive clade as a superfamily (Dendrobatoidea) composed of two families (one of which is new), six subfamilies (three new), and 16 genera (four new).
DISCOVERY OF BATRACHOTOXIN : THE LAUNCH OF THE FROG ALKALOID PROGRAM AT NIH
The determination of the structures of the batrachotoxins (BTXs), extremely toxic steroidal alkaloids found in the skins of the dart-poison frogs of the genus Phyllobates from Colombia in the 1960s
CHAPTER 43 – Neurotoxic Animal Poisons and Venoms
TLDR
Although there is a vast and fascinating array of aquatic creatures that produce toxins of clinical signifi cance and importance, discussion in this chapter is limited to encounters with land-dwelling creatures.
BULLETIN OF ZOOLOGICAL NOMENCLATURE
For many years malacologists have used the binomen Conus fergusoni G.B. Sowerby III, 1873: 145, based on "several specimens collected at Panama by Mr Ferguson" for a common and distinctive species of
Asymmetric synthesis of batrachotoxin: Enantiomeric toxins show functional divergence against NaV
TLDR
Electrophysiological characterization of these molecules against NaV subtypes establishes the non-natural toxin enantiomer as a reversible antagonist of channel function, markedly different in activity from (−)-batrachotoxin.
Does batrachotoxin autoresistance coevolve with toxicity in Phyllobates poison‐dart frogs?
TLDR
Reconstructions suggest that BTX resistance arose at the root of Phyllobates, coinciding with the evolution of BTX secretion, but little or no further evolution of autoresistance seems to have occurred, despite large increases in toxicity throughout the history of these frogs.
...
1
2
3
...

References

SHOWING 1-5 OF 5 REFERENCES
Über das Hautsekret der Frösche
  • F. Flury
  • Chemistry
    Archiv für experimentelle Pathologie und Pharmakologie
  • 2005
Inhalt. seitr Einle i tung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 320 I. U b e r d i e p h a i ' m a k o l o g i s e h e n W i r k u n g e n d e s t t a u t s e k r e t s v o n R
Capacity of muscle fiber membrane.
Using two or three microelectrodes inserted into single muscle fibers of the toad sartorius, the electric impedance of the muscle fiber membrane was measured with a.c. between 25 and 1500 cps. It was
A rapid micromethod for estimation of non-volatile organic matter.
  • M. J. Johnson
  • Medicine, Biology
    The Journal of biological chemistry
  • 1949