The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions.

@article{Tanoue2004TheVV,
  title={The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions.},
  author={Akito Tanoue and Shuji Ito and Kenji Honda and Sayuri Oshikawa and Yoko Kitagawa and Taka-Aki Koshimizu and Toyoki Mori and Gozoh Tsujimoto},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={113 2},
  pages={302-9}
}
The neurohypophyseal peptide [Arg(8)]-vasopressin (AVP) exerts major physiological actions through three distinct receptor isoforms designated V1a, V1b, and V2. Among these three subtypes, the vasopressin V1b receptor is specifically expressed in pituitary corticotrophs and mediates the stimulatory effect of vasopressin on ACTH release. To investigate the functional roles of V1b receptor subtypes in vivo, gene targeting was used to create a mouse model lacking the V1b receptor gene (V1bR… CONTINUE READING

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