The vasodilator action of parathyroid hormone fragments on isolated perfused rat kidney

@article{Musso1989TheVA,
  title={The vasodilator action of parathyroid hormone fragments on isolated perfused rat kidney},
  author={Martine Musso and Mariette Barthehnebs and Jl. Imbs and Martin C. Plante and Claudine Bollack and Joseph Helwig},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1989},
  volume={340},
  pages={246-251}
}
The renal vasodilator responses to various fragments of PTH were quantified on a model of isolated perfused rat kidney (IPK), under non-filtering conditions. The 1–34 fragment of bovine PTH, its Nle analogue and rat PTH, injected in sequential cumulative doses, caused concentration-dependent vasodilatation in the vasculature of the IPK which was preconstricted with prostaglandin F2α. The EC50 of PTH for renal vasodilatation ranged from 1 to 2 nM for all PTH fragments and maximum vasodilatation… CONTINUE READING
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