The vascular disrupting agent, DMXAA, directly activates dendritic cells through a MyD88-independent mechanism and generates antitumor cytotoxic T lymphocytes.

@article{Wallace2007TheVD,
  title={The vascular disrupting agent, DMXAA, directly activates dendritic cells through a MyD88-independent mechanism and generates antitumor cytotoxic T lymphocytes.},
  author={Africa F Wallace and David F Larosa and Veena Kapoor and Jing Sun and Guanjun Cheng and Arminder Singh Jassar and Aaron Blouin and L. Y. Ching and Steven M. Albelda},
  journal={Cancer research},
  year={2007},
  volume={67 14},
  pages={7011-9}
}
5,6-Di-methylxanthenone-4-acetic acid (DMXAA) is a small molecule in the flavanoid class that has antitumor activity. Although classified as a "vascular disrupting agent," we have recently conducted studies showing that DMXAA has remarkable efficacy in a range of tumors, working primarily as an immune modulator that activates tumor-associated macrophages and induces a subsequent CD8(+) T-cell-mediated response. To more completely analyze the effect of DMXAA on CD8(+) T-cell generation, we… CONTINUE READING

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