The vascular dementia of Fabry's disease.

  title={The vascular dementia of Fabry's disease.},
  author={Mario F. Mendez and Trevor Stanley and N M Medel and Zheng Li and Dustin Tedesco},
  journal={Dementia and geriatric cognitive disorders},
  volume={8 4},
Fabry's disease, a rare X-linked disorder of glycosphingolipid metabolism, can present as an insidious dementia in middle or later life. This genetic disorder produces a deficiency of alpha-galactosidase A which results in the deposition of glycosphingolipids in blood vessel walls in the brain as well as in the kidney, heart, peripheral nerves, and other organs. Among the cerebrovascular manifestations of this disorder is a vascular dementia from involvement of multiple small penetrating blood… CONTINUE READING