The vascular bed as the primary target in the destruction of skin grafts by antiserum. II. Loss of sensitivity to antiserum in long-term xenografts of skin

@article{Jooste1981TheVB,
  title={The vascular bed as the primary target in the destruction of skin grafts by antiserum. II. Loss of sensitivity to antiserum in long-term xenografts of skin},
  author={S V Jooste and R B Colvin and Henry J. Winn},
  journal={The Journal of Experimental Medicine},
  year={1981},
  volume={154},
  pages={1332 - 1341}
}
Rat skin that survives for long periods of time on immunosuppressed mice becomes resistant to anti-graft serum and remains so for as long as it survives. When long-standing grafts are removed and placed on new immunosuppressed mice, they remain resistant to antiserum for as long as they survive. The acquired resistance to antiserum seems, therefore, to be due to changes in the grafts rather than to changes in their hosts. Furthermore, it was found that the acquisition of resistance is… 

Tables from this paper

The vascular bed as the primary target in the destruction of skin grafts by antiserum. I. Resistance of freshly placed xenografts of skin to antiserum

TLDR
It is shown that the initial period of resistance to antiserum is due to factors acting locally within the graft and is entirely uninfluenced by the regimen of immunosuppression or the protective dressings that are used, and supports the idea that the induction of vascular injury is an essential step in antisera-mediated damage to tissue grafts.

Immunologically nonspecific mechanisms of tissue destruction in the rejection of skin grafts

TLDR
In all cases, the inflammation and tissue damage were confined sharply to the grafted skin, showing clearly that nonspecific or indirect tissue destruction is entirely consistent with highly selective destruction of grafted tissues.

Immunology of xenotransplantation.

Immunobiology of Xenografting in Rodents

TLDR
Perhaps the most important factor in the utility of these animals is the ability to perform large numbers of solid-organ grafts in a cost-effective manner consistent with modern concerns for animal welfare.

Molecular and Cellular Hurdles to Xenotransplantation

The transplantation of organs, tissues, or cells between individuals of different species has been of increasing interest in recent years because the use of animals as organ and tissue donors as a

Transplant Arteriopathy Tolerance, Mixed Chimerism, and Chronic

TLDR
In this setting, vasculopathy develops in the presence of H-2 gene-determined incompatibility even with minimal conventional immune reactivity, which supports the conclusion that immunological responses to donor-specific incompatibilities are a major factor in producing “chronic” transplant rejection, including the arteriopathy commonly present.

Delayed rejection of soluble tumor necrosis factor receptor-secreting tumor allografts.

TLDR
Prolongation of graft survival can be achieved by genetically altering transplanted tissue to secrete soluble cytokine receptors when transplanted into minor histocompatibility antigen-disparate allogeneic recipients.

A Primer on Xenotransplantation

TLDR
The past few years have brought significant progress in defining the hurdles to xenotransplantation and progress in overcoming the immunologic and physiologic hurdles in this field.

References

SHOWING 1-8 OF 8 REFERENCES

The vascular bed as the primary target in the destruction of skin grafts by antiserum. I. Resistance of freshly placed xenografts of skin to antiserum

TLDR
It is shown that the initial period of resistance to antiserum is due to factors acting locally within the graft and is entirely uninfluenced by the regimen of immunosuppression or the protective dressings that are used, and supports the idea that the induction of vascular injury is an essential step in antisera-mediated damage to tissue grafts.

Acute destruction of rat skin grafts by alloantisera.

TLDR
Rat skin transplanted to mice or to allogeneic rats can be acutely and severely damaged by injecting the graft recipients with alloimmune serum of appropriate specificity, and combinations of the two sera can act synergistically to destroy LBN skin that has been grafted to immunosuppressed mice.

ACUTE DESTRUCTION BY HUMORAL ANTIBODY OF RAT SKIN GRAFTED TO MICE

TLDR
The failure of MARS to cause tissue damage in mice whose circulating PMN have been reduced to very low levels by treatment with nitrogen mustard or more specifically with an anti-PMN serum suggests that C-mediated cytolysis is unimportant in graft destruction and that the role of C lies in its ability to generate chemotactic factors.

Sensitivity of long-standing xenografts of rat hearts to humoral antibodies.

TLDR
It is demonstrated that long-standing primarily vascularized rat-to-mouse cardiac xenografts, unlike skin, remain fully sensitive to antiserum-mediated destruction, even in mice also bearing a long- standing skin graft that is resistant to antisonum.

Fibrin gel investment associated with line 1 and line 10 solid tumor growth, angiogenesis, and fibroplasia in guinea pigs. Role of cellular immunity, myofibroblasts, microvascular damage, and infarction in line 1 tumor regression.

TLDR
Line 1 and line 10 tumors became invested in a fibrin-gel cocoon within hours after transplantation to the subcutaneous spaces of unsensitized syngeneic inbred Sewall Wright strain 2 guinea pigs, suggesting that activation of the clotting and/or fibrinolytic systems by tumor cells may itself provide sufficient stimulus for induction of tumor angiogenesis without requiring a separate tumorAngiogenesis factor.

Destruction of rat skin grafts by humoral antibody.

In vivo methods for the assessment of antibody-mediated tumor immunity.

  • H. Winn
  • Biology
    National Cancer Institute monograph
  • 1972