The vascular activity of some isoflavone metabolites: implications for a cardioprotective role

  title={The vascular activity of some isoflavone metabolites: implications for a cardioprotective role},
  author={Jaye P. F. Chin-Dusting and Lisa J. Fisher and Tamara V. Lewis and Anna Piekarska and Paul J. Nestel and Alan Husband},
  journal={British Journal of Pharmacology},
Legume‐derived isoflavones such as genistein, diadzein and equol have been associated with a reduction in risk of cardiovascular disease. In the current study, we explore the vascular activity of several isoflavone metabolites namely dihydrodaidzein, cis and trans‐tetrahydrodaidzein and dehydroequol for potential cardioprotective properties. Rat isolated aortic rings were used. 17β‐oestradiol, equol, and all four of the metabolites studied significantly antagonized contractile responses to… 
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