The vascular activity of some isoflavone metabolites: implications for a cardioprotective role

@article{ChinDusting2001TheVA,
  title={The vascular activity of some isoflavone metabolites: implications for a cardioprotective role},
  author={Jaye P. F. Chin-Dusting and Lisa J. Fisher and Tamara V. Lewis and Anna Piekarska and Paul J. Nestel and Alan Husband},
  journal={British Journal of Pharmacology},
  year={2001},
  volume={133}
}
Legume‐derived isoflavones such as genistein, diadzein and equol have been associated with a reduction in risk of cardiovascular disease. In the current study, we explore the vascular activity of several isoflavone metabolites namely dihydrodaidzein, cis and trans‐tetrahydrodaidzein and dehydroequol for potential cardioprotective properties. Rat isolated aortic rings were used. 17β‐oestradiol, equol, and all four of the metabolites studied significantly antagonized contractile responses to… 
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References

SHOWING 1-10 OF 28 REFERENCES
Renal and vascular actions of equol in the rat
TLDR
Equol is a modest natriuretic and vasorelaxant agent in the rat and may be a hypotensive actions of dietary equol precursors (daidzein).
Effect of 17β-estradiol in hypercholesterolemic rabbits with severe endothelial dysfunction.
TLDR
It is demonstrated that estrogen treatment may exert protection against atherosclerosis even in patients with severe endothelial dysfunction, and 17β-Estradiol treatment significantly increased EDNO production under these conditions as well.
Phytoestrogens and bone.
TLDR
The only positive effects of phytoestrogens on bone observed so far in post-menopausal women have been small and limited to the lumbar vertebrae.
4Phytoestrogens and coronary heart disease
Native and oxidized low‐density lipoproteins have different inhibitory effects on endothelium‐derived relaxing factor in the rabbit aorta
TLDR
It is demonstrated that native and OXLDL influence the response to EDRF in isolated aorta, and it is suggested that these lipoproteins may contribute to the attenuation of responses to E DRF found in isolated arteries from hypercholesterolaemic and atherosclerotic animals.
Plant derived estrogens relax rat mesenteric artery in vitro.
Phytoestrogens and coronary heart disease.
TLDR
The soy phytoestrogens favourably influence coronary artery reactivity and inhibit the progression of atherosclerosis in the coronary, iliac and common and internal carotid arteries.
Soy protein, isoflavones and cardiovascular disease risk.
TLDR
The increased consumption of products containing soy protein may displace foods relatively high in saturated fat and cholesterol from the diet and hence have an indirect blood cholesterol-lowering effect.
Contractile responses to histamine, serotonin, and angiotensin II are impaired by 17 beta-estradiol in human internal mammary arteries in vitro.
TLDR
It is concluded that short-term incubation with 17 beta-estradiol reduces the maximal contractile responses to serotonin, histamine, and angiotensin II, which may contribute to the proposed beneficial role of estrogen replacement therapy on the incidence of myocardial infarction in postmenopausal women.
Soy, disease prevention, and prostate cancer.
  • M. Moyad
  • Biology
    Seminars in urologic oncology
  • 1999
Population-based studies from around the world support the theory that soy products and their constituents, primarily the isoflavones or phytoestrogens, are partly responsible for the lower rates of
...
...