The various aggregation states of beta-amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression.

@article{Tamagno2006TheVA,
  title={The various aggregation states of beta-amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression.},
  author={Elena Tamagno and Paola Bardini and Michela Guglielmotto and Oliviero Danni and Massimo Tabaton},
  journal={Free radical biology & medicine},
  year={2006},
  volume={41 2},
  pages={202-12}
}
The amyloid cascade hypothesis suggests that the insoluble and fibrillar form of beta-amyloid (A beta) may play a primary pathogenic role in Alzheimer disease at the molecular level. However, neither the rate of dementia nor the extent of neuronal change seems to correlate with the levels of amyloidotic plaques (i.e., aggregated/fibrillar A beta). Recent evidence suggests, however, that neurotoxicity may be exerted also by rather small soluble aggregates of A beta, including oligomers. To… CONTINUE READING
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